Pubblicazioni selezionate - dr. Antonio Sica

1. Mancino A, Schioppa T, Larghi P, Pasqualini P, Nebuloni M, Chen I-Hsuan, Sozzani S, Austyn JM, Mantovani A, Sica A.  Divergent Effects of Hypoxia on Dendritic Cell Functions. Blood In press.
2. Mantovani A, Allavena P, Sica A and Frances Balkwill. Cancer-related Inflammation. Nature In press
3. Sica A, Larghi P, Mancino A, Rubino L, Porta C, Totaro MG, Rimoldi M, Biswas SK, Allavena P, Mantovani A. Macrophage polarization in tumour progression. Semin Cancer Biol. 2008
4. Sica A. and Bronte V. Altered macrophage differentiation and immune dysfunctions during tumor development. J. Clin. Invest., 2007, 117:1155-66.
5. Saccani A, Schioppa T, Porta C, Biswas SK, Nebuloni M, Vago L, Bottazzi B, Colombo MP, Mantovani A, Sica A. p50 nuclear factor-kappaB overexpression in tumor-associated macrophages inhibits M1 inflammatory responses and antitumor resistance. Cancer Res. 2006, 66:11432-11440.
6. Sica A., Schioppa T, Mantovani A and Allavena P. Tumor-Associated Macrophages are a distinct M2 polarized population promoting tumor progression: potential targets of anti-cancer therapy. Eur.J.Cancer 2006, 42:717-727.
7. Biswas SK, Gangi L, Paul S, Schioppa T, Saccani A, Sironi M, Bottazzi B, Doni A, Bronte V, Pasqualini F, Vago L, Nebuloni M, Mantovani A, Sica A. A distinct and unique transcriptional programme expressed by tumor-associated macrophages: defective NF-{kappa}B and enhanced IRF-3/STAT1 activation. Blood. 2006, 107: 2112-2122.
8. T. Schioppa, B Uranchimeg, A Saccani, Subhra K. Biswas, A Rapisarda, S Bernasconi, S Saccani, G Natoli, M Nebuloni, L Vago, A Mantovani, G Melillo and A Sica. 2003. Regulation of the chemokine receptor CXCR4 by hypoxia. J. Exp. Med. 198: 1391-1402.
9. Alberto Mantovani, Antonio Sica. 2003. The jury on radicals is still out Trends in Immunol. 24: 234
10. Alberto Mantovani, Silvano Sozzani, Massimo Locati, Paola Allavena and Antonio Sica 2002. Tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes. Trends in Immunol. 23(11):549-55.
11. A. Saccani, S.Saccani, S. Orlando, S. Bernasconi, P.Ghezzi, A. Mantovani and A. Sica. (2000) Redox Regulation of Chemokine Receptor Expression. Proc.Natl. Acad. Sci. 97: 2761-2766.
12. A. Sica, A. Saccani, B. Bottazzi, S. Bernasconi, P. Allavena, Brancatelli Gaetano, Francesca Fei, Graig LaRosa, Chris Scotton, Frances Balkwill, and Alberto Mantovani. (2000) Defective expression of the monocyte chemotactic protein-1 receptor CCR2 in macrophages associated with human ovarian carcinoma. J. Immunol. 164: 733-738.
13. A. Sica, A. Saccani, B. Bottazzi, N. Polentarutti, A. Vecchi, Jo Van Damme, A. Mantovani.(2000) Autocrine Production of Interleukin-10 (IL-10) Mediates Defective IL-12 Production and NF-kB Activation in Tumor-Associated Macrophages.J. Immunol.164:762-767.
14. A. Sica, A. Saccani, A. Borsatti, C. A. Power, T. Wells, W. Luini, N. Polentarutti, S. Sozzani, and A. Mantovani. (1997). Bacterial lipopolisaccharide rapidly inhibits expression of C-C chemokine receptors in human monocytes J. Exp. Med. 185: 969-974.
15. A. Sica, T-H Tan, N. Rice, M. Kretzschmar, P. Ghosh, and Howard Young. 1992. The c-rel protooncogene product c-Rel but not NF-kB Binds to the intronic region of the human interferon-gamma gene at a site related to an interferon-stimulable response element. Proc. Natl. Acad. Sci. USA, 89: 1741-1744.